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Article

Regulation of the PDK4 isozyme by the Rb-E2F1 complex.

The Journal of biological chemistry - 10 Oct 2008

Hsieh Michael C F, Das Debopriya, Sambandam Nandakumar, Zhang Michael Q, Nahlé Zaher

Abstract excerpt

Loss of the transcription factor E2F1 elicits a complex metabolic phenotype in mice underscored by reduced adiposity and protection from high fat diet-induced diabetes. Here, we demonstrate that E2F1 directly regulates the gene encoding PDK4 (pyruvate dehydrogenase kinase 4), a key nutrient sensor and modulator of glucose homeostasis that is chronically elevated in obesity and diabetes and acutely induced under...

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Source

Identifiers

PMID: 18667418
DOI: 10.1074/jbc.M802418200

Genes

PDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of the PDK4 isozyme by the Rb-E2F1 complex.PMID 18667418Read ↗

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