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Article

Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA.

Molecular cell - 11 Sept 2009

Yunus Ali A, Lima Christopher D

Abstract excerpt

Siz1 is a founding member of the Siz/PIAS RING family of SUMO E3 ligases. The X-ray structure of an active Siz1 ligase revealed an elongated tripartite architecture comprised of an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain we term the SP-CTD. Structure-based mutational analysis and biochemical studies show that the SP-RING and SP-CTD are required for...

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Identifiers

PMID: 19748360
DOI: 10.1016/j.molcel.2009.07.013
PMCID: PMC2771690

Genes

PCNA

Provenance

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Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA.PMID 19748360Read ↗

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