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Article

CRL4s: the CUL4-RING E3 ubiquitin ligases.

Trends in biochemical sciences - 1 Nov 2009

Jackson Sarah, Xiong Yue

Abstract excerpt

The evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3 ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three founding cullins conserved from yeast to humans, uses a large beta-propeller protein, DDB1, as a linker to interact with a subset of WD40 proteins that serve as substrate receptors, forming as many as 90 E3 complexes in mammals. Many...

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Source

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Identifiers

PMID: 19818632
DOI: 10.1016/j.tibs.2009.07.002
PMCID: PMC2783741

Genes

DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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