Article
Expression of NAT2 in immune system cells and the relation of NAT2 gene polymorphisms in the anti-tuberculosis therapy in Mexican mestizo population.
Molecular biology reports - 1 Dec 2014
Salazar-González R, Gómez R, Romano-Moreno S, Medellín-Garibay S, Núñez-Ruíz A, Magaña-Aquino M, Milán-Segovia R C, Portales-Pérez D P
Abstract excerpt
Arylamine N-acetyltransferase 2 (NAT2) metabolizes isoniazid (INH) and Single Nucleotide Polymorphisms (SNP) responsible for its activity has been reported. The aim of this study in the Mexican mestizo population was to evaluate NAT2 expression at the protein level in immune cells, as well as the distribution and frequency of six NAT2 SNPs and their association with anti-TB therapy, by measuring the plasma levels...
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