Article

Genetic Polymorphisms of N-acetyl Transferase 2 and the Risk of Hepatotoxicity in Patients on Isoniazid Preventive Therapy at Kenyatta National Hospital

2023-06-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> N-acetyl transferase (<italic>NAT2</italic>) affects metabolism and disposition of isoniazid. Polymorphisms of <italic>NAT2</italic> may affect pharmacokinetics of isoniazid (INH) by decreasing concentration of active drug in fast acetylators. High concentrations of drug in slow acetylators may lead to hepatotoxicity; this affects clinical outcomes of patients on...

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Literature Corpus work: 01daafe2-3183-5a05-9c76-3fac60e71b8f
DOI: 10.21203/rs.3.rs-3073692/v1

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