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Article

Full-gene sequencing analysis of NAT2 and its relationship with isoniazid pharmacokinetics in Venezuelan children with tuberculosis.

Pharmacogenomics - 1 Feb 2014

Verhagen Lilly M, Coenen Marieke Jh, López Diana, García Juan F, de Waard Jacobus H, Schijvenaars Mascha M V A P, Hermans Peter W M, Aarnoutse Rob E

Abstract excerpt

BACKGROUND: Genetic variants in NAT2 are associated with pharmacokinetic variation of isoniazid, the cornerstone of antituberculosis treatment. We investigated the acetylator genotype and phenotype in children on antituberculosis treatment that were previously shown to have low plasma isoniazid l...

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Source

Identifiers

PMID: 24533708
DOI: 10.2217/pgs.13.230

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24533708-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Full-gene sequencing analysis of NAT2 and its relationship with isoniazid pharmacokinetics in Venezuelan children with tuberculosis.PMID 24533708Read ↗

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Efficacy, safety, and pharmacokinetics of isoniazid affected by NAT2 polymorphisms in patients with tuberculosis: A systematic review.Semantic proximity Read ↗

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