A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk.

doi:10.1210/jc.2013-3766

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk.

The Journal of clinical endocrinology and metabolism - 1 Apr 2014

Torekov S S, Harsløf T, Rejnmark L, Eiken P, Jensen J B, Herman A P, Hansen T, Pedersen O, Holst J J, Langdahl B L

Abstract excerpt

CONTEXT: Food ingestion decreases bone resorption, and glucose-dependent insulinotropic polypeptide (GIP) may mediate this effect. Mice overexpressing GIP have increased osteoblast activity and are rescued from age-related bone loss, whereas GIPR knockout mice have decreased cortical bone mass and compromised bone quality. Carriers of the functional variant GIPR Glu354Gln (rs1800437) have higher plasma glucose 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Density

Share to Cohort Studies

Share to Femur Neck

Share to Fractures, Bone

Share to Gene Frequency

Share to Genetic Association Studies

Share to Osteoporosis, Postmenopausal

Source

Open in PubMed

Identifiers

PMID: 24446656
DOI: 10.1210/jc.2013-3766

Genes

GIPR
GIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk.PMID 24446656Read ↗

Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.Semantic proximity Read ↗

Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.Semantic proximity Read ↗

Glycaemic and bodyweight effects of <i>GIPR</i> coding variation reflect differences in both surface expression and intrinsic functional impairmentSemantic proximity Read ↗

Genetically-proxied impaired GIPR signalling and risk of 6 cancersSemantic proximity Read ↗

Genetically proxied impaired GIPR signaling and risk of 6 cancersSemantic proximity Read ↗

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.Semantic proximity Read ↗

Link between GIP and osteopontin in adipose tissue and insulin resistance.Semantic proximity Read ↗

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variantSemantic proximity Read ↗

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.Semantic proximity Read ↗

Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release.Semantic proximity Read ↗

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.