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Article

Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.

The Journal of clinical endocrinology and metabolism - 12 Jul 2024

Styrkarsdottir Unnur, Tragante Vinicius, Stefansdottir Lilja, Thorleifsson Gudmar, Oddsson Asmundur, Sørensen Erik, Erikstrup Christian, Schwarz Peter, Jørgensen Henrik Løvendahl, Lauritzen Jes Bruun, Brunak Søren, Knowlton Kirk U, Nadauld Lincoln D, Ullum Henrik, Pedersen Ole Birger Vesterager, Ostrowski Sisse Rye, Holm Hilma, Gudbjartsson Daniel F, Sulem Patrick, Stefansson Kari

Abstract excerpt

CONTEXT: It is not clear if antagonizing the GIP (glucose-dependent insulinotropic polypeptide) receptor (GIPR) for treatment of obesity is likely to increase the risk of fractures, or to lower bone mineral density (BMD) beyond what is expected with rapid weight loss. OBJECTIVE: The objective of this study was to investigate the risk of fracture and BMD of sequence variants in GIPR that reduce the activity of the...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 38118020
DOI: 10.1210/clinem/dgad734
PMCID: PMC11244190

Genes

GIPR
GIP

Variants

rs143430880
rs139215588
rs143430880
rs1800437
rs139215588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.PMID 38118020Read ↗

A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk.Semantic proximity Read ↗

Evaluation of the Effect of Sodium-Glucose Cotransporter 2 Inhibition on Fracture Risk: Evidence From Mendelian Randomization and Genetic Association Study.Semantic proximity Read ↗

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Genetic variants in obesity-related genes and the risk of osteoporotic fracture. The Hortega Follow-up Study.Semantic proximity Read ↗

Glycaemic and bodyweight effects of <i>GIPR</i> coding variation reflect differences in both surface expression and intrinsic functional impairmentSemantic proximity Read ↗

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Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects.Semantic proximity Read ↗

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