Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.

doi:10.1210/jc.2011-2444

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Article

Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.

The Journal of clinical endocrinology and metabolism - 1 May 2012

Sonestedt Emily, Lyssenko Valeriya, Ericson Ulrika, Gullberg Bo, Wirfält Elisabet, Groop Leif, Orho-Melander Marju

Abstract excerpt

CONTEXT: A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis. OBJECTIVE: Our objective was to examine the...

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PMID: 22399504
DOI: 10.1210/jc.2011-2444

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GIPR

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