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Article

Link between GIP and osteopontin in adipose tissue and insulin resistance.

Diabetes - 1 Jun 2013

Ahlqvist Emma, Osmark Peter, Kuulasmaa Tiina, Pilgaard Kasper, Omar Bilal, Brøns Charlotte, Kotova Olga, Zetterqvist Anna V, Stancáková Alena, Jonsson Anna, Hansson Ola, Kuusisto Johanna, Kieffer Timothy J, Tuomi Tiinamaija, Isomaa Bo, Madsbad Sten, Gomez Maria F, Poulsen Pernille, Laakso Markku, Degerman Eva, Pihlajamäki Jussi, Wierup Nils, Vaag Allan, Groop Leif, Lyssenko Valeriya

Abstract excerpt

Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. Since glucose-dependent insulinotropic polypeptide (GIP) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate OPN expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23349498
DOI: 10.2337/db12-0976
PMCID: PMC3661641

Genes

GIP
GIPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Link between GIP and osteopontin in adipose tissue and insulin resistance.PMID 23349498Read ↗

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