Article

Molecular crowding: impacts on the activity of the 10-23 DNAzyme

2026-07-01

Abstract excerpt

The growing number of approved nucleic acid therapeutics illustrates the potential to treat diseases by targeting their genetic blueprints in vivo . The 10-23 DNAzyme is capable of cleaving a wide range of target RNA with high selectivity. However, its poor performance in vivo restricts its therapeutic application as gene silencing agent. Studies on ribozymes have shown that the crowded environment in cells and...

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Literature Corpus work: 3831f558-5fcd-5d8b-b370-0e5c9ee9ca8d
DOI: 10.64898/2026.06.30.735450

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