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Article

Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme.

Nucleic acids research - 1 Jan 2015

Lee Hui-Ting, Kilburn Duncan, Behrouzi Reza, Briber Robert M, Woodson Sarah A

Abstract excerpt

The native structure of the Azoarcus group I ribozyme is stabilized by the cooperative formation of tertiary interactions between double helical domains. Thus, even single mutations that break this network of tertiary interactions reduce ribozyme activity in physiological Mg(2+) concentrations. H...

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Identifiers

PMID: 25541198
DOI: 10.1093/nar/gku1335
PMCID: PMC4333387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25541198-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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