ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.

doi:10.1038/srep03755

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Article

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.

Scientific reports - 20 Jan 2014

Matsuo Hirotaka, Nakayama Akiyoshi, Sakiyama Masayuki, Chiba Toshinori, Shimizu Seiko, Kawamura Yusuke, Nakashima Hiroshi, Nakamura Takahiro, Takada Yuzo, Oikawa Yuji, Takada Tappei, Nakaoka Hirofumi, Abe Junko, Inoue Hiroki, Wakai Kenji, Kawai Sayo, Guang Yin, Nakagawa Hiroko, Ito Toshimitsu, Niwa Kazuki, Yamamoto Ken, Sakurai Yutaka, Suzuki Hiroshi, Hosoya Tatsuo, Ichida Kimiyoshi, Shimizu Toru, Shinomiya Nariyoshi

Abstract excerpt

Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, but its involvement in renal underexcretion (RUE) hyperuricemia, the most prevalent subtype, is not clearly explained so far. In this study, the association analysis with 644 hyperuricemia patients and 1,623 controls in male Japanese...

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PMID: 24441388
DOI: 10.1038/srep03755
PMCID: PMC3895923

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ABCG2

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