Article
Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.
Scientific reports - 9 Jun 2014
Nakayama Akiyoshi, Matsuo Hirotaka, Nakaoka Hirofumi, Nakamura Takahiro, Nakashima Hiroshi, Takada Yuzo, Oikawa Yuji, Takada Tappei, Sakiyama Masayuki, Shimizu Seiko, Kawamura Yusuke, Chiba Toshinori, Abe Junko, Wakai Kenji, Kawai Sayo, Okada Rieko, Tamura Takashi, Shichijo Yuka, Akashi Airi, Suzuki Hiroshi, Hosoya Tatsuo, Sakurai Yutaka, Ichida Kimiyoshi, Shinomiya Nariyoshi
Abstract excerpt
Gout/hyperuricemia is a common multifactorial disease having typical environmental risks. Recently, common dysfunctional variants of ABCG2, a urate exporter gene also known as BCRP, are revealed to be a major cause of gout/hyperuricemia. Here, we compared the influence of ABCG2 dysfunction on serum uric acid (SUA) levels with other typical risk factors in a cohort of 5,005 Japanese participants. ABCG2 dysfunction...
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