Article
A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout.
Drug metabolism and pharmacokinetics - 1 Jan 2014
Sakiyama Masayuki, Matsuo Hirotaka, Shimizu Seiko, Nakashima Hiroshi, Nakayama Akiyoshi, Chiba Toshinori, Naito Mariko, Takada Tappei, Suzuki Hiroshi, Hamajima Nobuyuki, Ichida Kimiyoshi, Shimizu Toru, Shinomiya Nariyoshi
Abstract excerpt
Gout, a common disease, is a consequence of hyperuricemia, and increases the risks of hypertension, cardiovascular diseases, cerebrovascular diseases and renal failure. Gout can be classified into 3 types: the renal underexcretion (RUE) type, renal overload type and combined type. RUE type is a major type of gout; however, its genetic causes are still unclear. Since human organic anion transporter 4...
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