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Article

ABCG2/BCRP dysfunction as a major cause of gout.

Nucleosides, nucleotides & nucleic acids - 1 Dec 2011

Matsuo Hirotaka, Takada Tappei, Ichida Kimiyoshi, Nakamura Takahiro, Nakayama Akiyoshi, Suzuki Hiroshi, Hosoya Tatsuo, Shinomiya Nariyoshi

Abstract excerpt

Recent genome-wide association studies showed that serum uric acid (SUA) levels relate to ABCG2/BCRP gene, which locates in a gout-susceptibility locus revealed by a genome-wide linkage study. Together with the ABCG2 characteristics, we hypothesized that ABCG2 transports urate and its dysfunction causes hyperuricemia and gout. Transport assays showed ATP-dependent transport of urate via ABCG2. Kinetic analysis...

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Source

Identifiers

PMID: 22132966
DOI: 10.1080/15257770.2011.633954

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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