Article
ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans.
Nucleosides, nucleotides & nucleic acids - 1 Dec 2011
Nakayama Akiyoshi, Matsuo Hirotaka, Takada Tappei, Ichida Kimiyoshi, Nakamura Takahiro, Ikebuchi Yuki, Ito Kousei, Hosoya Tatsuo, Kanai Yoshikatsu, Suzuki Hiroshi, Shinomiya Nariyoshi
Abstract excerpt
The ATP-binding cassette, subfamily G, member 2 (ABCG2/BCRP) gene encodes a well-known transporter, which exports various substrates including nucleotide analogs such as 3'-azido-3'-deoxythymidine (AZT). ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Becuase urate...
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