Article
ABCG2 dysfunction increases the risk of renal overload hyperuricemia.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2014
Matsuo Hirotaka, Takada Tappei, Nakayama Akiyoshi, Shimizu Toru, Sakiyama Masayuki, Shimizu Seiko, Chiba Toshinori, Nakashima Hiroshi, Nakamura Takahiro, Takada Yuzo, Sakurai Yutaka, Hosoya Tatsuo, Shinomiya Nariyoshi, Ichida Kimiyoshi
Abstract excerpt
ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is identified as a high-capacity urate exporter, and its dysfunction has an association with serum uric acid levels and gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate "overproduction type," "underexcretion type," and "combined type" based on only renal urate excretion, without considering an extra-renal pathway...
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