Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations.

Molecular genetics and metabolism - 1 Jul 2022

Toyoda Yu, Nakayama Akiyoshi, Nakatochi Masahiro, Kawamura Yusuke, Nakaoka Hirofumi, Yamamoto Ken, Shimizu Seiko, Ooyama Hiroshi, Ooyama Keiko, Shimizu Toru, Nagase Mitsuo, Hidaka Yuji, Ichida Kimiyoshi, Inoue Ituro, Shinomiya Nariyoshi, Matsuo Hirotaka

Abstract excerpt

Despite progress in understanding of the genetic basis of gout, the precise factors affecting differences in gout susceptibility among different gout subtypes remain unclear. Using clinically diagnosed gout patients, we conducted a genome-wide meta-analysis of two distinct gout subtypes: the renal overload type and the renal underexcretion type. We provide genetic evidence at a genome-wide level of significance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Gout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 35148957
DOI: 10.1016/j.ymgme.2022.01.100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations.PMID 35148957Read ↗

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.Semantic proximity Read ↗

ABCG2 dysfunction increases the risk of renal overload hyperuricemia.Semantic proximity Read ↗

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.Semantic proximity Read ↗

A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout.Semantic proximity Read ↗

Hyperuricemia Subtypes Classified According to Renal Uric Acid Handling Manifesting Distinct Phenotypic and Genetic Profiles in People With Gout.Semantic proximity Read ↗

Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.Semantic proximity Read ↗

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.Semantic proximity Read ↗

Common dysfunctional variants in ABCG2 are a major cause of early-onset goutSemantic proximity Read ↗

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.Semantic proximity Read ↗

Identification of ABCG2 dysfunction as a major factor contributing to gout.Semantic proximity Read ↗

ABCG2/BCRP dysfunction as a major cause of gout.Semantic proximity Read ↗

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.