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Article

Mdm2 is required for maintenance of the nephrogenic niche.

Developmental biology - 1 Mar 2014

Hilliard Sylvia A, Yao Xiao, El-Dahr Samir S

Abstract excerpt

The balance between nephron progenitor cell (NPC) renewal, survival and differentiation ultimately determines nephron endowment and thus susceptibile to chronic kidney disease and hypertension. Embryos lacking the p53-E3 ubiquitin ligase, Murine double minute 2 (Mdm2), die secondary to p53-mediated apoptosis and growth arrest, demonstrating the absolute requirement of Mdm2 in embryogenesis. Although Mdm2 is...

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Identifiers

PMID: 24440154
DOI: 10.1016/j.ydbio.2014.01.009
PMCID: PMC3951515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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