Article
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.
Kidney international - 1 Mar 2018
Combes Alexander N, Wilson Sean, Phipson Belinda, Binnie Brandon B, Ju Adler, Lawlor Kynan T, Cebrian Cristina, Walton Sarah L, Smyth Ian M, Moritz Karen M, Kopan Raphael, Oshlack Alicia, Little Melissa H
Abstract excerpt
The regulation of final nephron number in the kidney is poorly understood. Cessation of nephron formation occurs when the self-renewing nephron progenitor population commits to differentiation. Transcription factors within this progenitor population, such as SIX2, are assumed to control expression of genes promoting self-renewal such that homozygous Six2 deletion results in premature commitment and an early halt...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Cell Proliferation
- Cell Self Renewal
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Genotype
- Haploinsufficiency
- Heterozygote