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Article

Pax2 in development and renal disease

1 Jan 1999

Abstract excerpt

Pax genes are associated with a variety of developmental mutations in mouse and man that are gene dosage sensitive, or haploinsufficient. The Pax2 gene encodes a DNA binding, transcription factor whose expression is essential for the development of the renal epithelium. Both gain and loss of function mutants in the mouse demonstrate a requirement for Pax2 in the conversion of metanephric mesenchymal precursor...

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PMID: 10535325
DOI: 10.1387/ijdb.10535325

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