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Article

Notch signaling promotes nephrogenesis by downregulating Six2

16 Sept 2016

Abstract excerpt

During nephrogenesis, multipotent mesenchymal nephron progenitors develop into distinct epithelial segments. Each nephron segment has distinct cell types and physiological function. In the current model of kidney development, Notch signaling promotes the formation of proximal tubules and represses the formation of distal tubules. Here, we present a novel role of Notch in nephrogenesis. We show in mice that...

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PMID: 27633993
DOI: 10.1242/dev.143503

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