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Article

Regulation of kidney development by the Mdm2/Mdm4–p53 axis

18 Jan 2017

Abstract excerpt

While p53 activity is required for tumour suppression, unconstrained p53 activity on the other hand is detrimental to the organism, resulting in inappropriate cellular death or proliferation defects. Unimpeded p53 activity is lethal in the developing embryo, underlining the need for maintaining a tight control on p53 activity during this period. The critical role of the negative regulators of p53, Mdm2 and Mdm4,...

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PMID: 28096292
DOI: 10.1093/jmcb/mjx005

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