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Article

MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury.

Cell death & disease - 24 Nov 2016

Thomasova Dana, Ebrahim Martrez, Fleckinger Kristina, Li Moying, Molnar Jakob, Popper Bastian, Liapis Helen, Kotb Ahmed M, Siegerist Florian, Endlich Nicole, Anders Hans-Joachim

Abstract excerpt

Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation. MDM2 is highly expressed in the unchallenged tubular epithelial cells and we hypothesized that MDM2 is necessary for their survival and homeostasis. MDM2 knockdown by siRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27882940
DOI: 10.1038/cddis.2016.390
PMCID: PMC5260907

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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