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Article

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice.

Neurobiology of aging - 1 Jun 2014

Minogue Aedín M, Jones Raasay S, Kelly Ronan J, McDonald Claire L, Connor Thomas J, Lynch Marina A

Abstract excerpt

Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their neuroprotective properties leading to chronic neurodegeneration. Here, we sought to characterize inflammatory changes in a mouse model of Alzheimer's disease and to delineate differences between...

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Source

Identifiers

PMID: 24439957
DOI: 10.1016/j.neurobiolaging.2013.12.026

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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