Article
Microglia actions in Alzheimer’s disease.
Acta neuropathologica - 1 Oct 2013
Prokop Stefan, Miller Kelly R, Heppner Frank L
Abstract excerpt
The identification of microglia-associated, neurological disease-causing mutations in patients, combined with studies in mouse models has highlighted microglia, the brain’s intrinsic myeloid cells, as key modulators of pathogenesis and disease progression in neurodegenerative diseases. In Alzheimer’s disease (AD) in particular, the activation and accumulation of microglial cells around b-Amyloid (Ab) plaques has...
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