Article
Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2008
Jimenez Sebastian, Baglietto-Vargas David, Caballero Cristina, Moreno-Gonzalez Ines, Torres Manuel, Sanchez-Varo Raquel, Ruano Diego, Vizuete Marisa, Gutierrez Antonia, Vitorica Javier
Abstract excerpt
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic change of microglial activation in the hippocampus of PS1xAPP model, from an...
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