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Different phenotypes of microglia in animal models of Alzheimer disease

8 Oct 2022

Abstract excerpt

Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer disease (AD) is microglial proliferation and activation concentrated around amyloid plaques in the brain. Recent research has revealed numerous microglial phenotypes related to aging and AD, apart from the traditional M1 and M2 types. Redox signalling modulates the...

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PMID: 36209099
DOI: 10.1186/s12979-022-00300-0

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