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Article

Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction.

Neurology - 23 May 2000

Yaffe K, Haan M, Byers A, Tangen C, Kuller L

Abstract excerpt

OBJECTIVE: APOE-epsilon4 increases the risk of cognitive decline, while elderly women who take estrogen may have less risk of cognitive decline. The authors sought to determine whether estrogen use modifies the association between APOE-epsilon4 and cognitive decline. METHOD: - As part of the Cardiovascular Health Study, 3,393 Medicare-eligible women (> or =65 years) were randomly selected and recruited from...

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Source

Identifiers

PMID: 10822435
DOI: 10.1212/wnl.54.10.1949

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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