Article
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.
The Journal of clinical investigation - 1 Feb 2014
Liu Lijun, Nam Minwoo, Fan Wei, Akie Thomas E, Hoaglin David C, Gao Guangping, Keaney John F, Cooper Marcus P
Abstract excerpt
Sirtuin 3 (SIRT3), an important regulator of energy metabolism and lipid oxidation, is induced in fasted liver mitochondria and implicated in metabolic syndrome. In fasted liver, SIRT3-mediated increases in substrate flux depend on oxidative phosphorylation (OXPHOS), but precisely how OXPHOS meets the challenge of increased substrate oxidation in fasted liver remains unclear. Here, we show that liver mitochondria...
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