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Article

Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.

Aging - 1 Feb 2011

Choudhury Mahua, Jonscher Karen R, Friedman Jacob E

Abstract excerpt

Aging is associated with various metabolic disorders that may have their origin in the liver, including non-alcoholic fatty liver disease, obesity, type 2 diabetes mellitus, and atherosclerosis. Although well-characterized in models of caloric restriction, relatively little is known about the role of sirtuins and acetylation under conditions of caloric excess. Sirtuins are NAD (+)-dependent protein deacetylases...

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Identifiers

PMID: 21386135
DOI: 10.18632/aging.100289
PMCID: PMC3082013

Genes

SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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