Article

Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liver

2019-04-02

Abstract excerpt

<h4>Summary</h4> Inefficient fasted-to-refed transitions are known to cause metabolic diseases. Thus, identifying mechanisms that may constitute molecular switches during such physiological transitions become crucial. Specifically, whether nutrients program a relay of interactions in master regulators, such as SIRT1, and affect their stability is underexplored. Here, we elucidate nutrient-dependent O-GlcNAcylatio...

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Literature Corpus work: 6763d697-49ae-5367-81ef-891e5e6016d3
DOI: 10.1101/597153

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