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Article

Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation.

Cell reports - 24 Aug 2021

Valera-Alberni Miriam, Joffraud Magali, Miro-Blanch Joan, Capellades Jordi, Junza Alexandra, Dayon Loïc, Núñez Galindo Antonio, Sanchez-Garcia Jose L, Valsesia Armand, Cercillieux Angelique, Söllner Flavia, Ladurner Andreas G, Yanes Oscar, Cantó Carles

Abstract excerpt

Mitochondria constantly undergo fusion and fission events, referred as mitochondrial dynamics, which determine mitochondrial architecture and bioenergetics. Cultured cell studies demonstrate that mitochondrial dynamics are acutely regulated by phosphorylation of the mitochondrial fission orchestrator dynamin-related protein 1 (Drp1) at S579 or S600. However, the physiological impact and crosstalk of these...

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Identifiers

PMID: 34433037
DOI: 10.1016/j.celrep.2021.109565
PMCID: PMC8411118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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