Article
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.
The Journal of clinical investigation - 1 Feb 2014
D'Amico Gabriela, Korhonen Emilia A, Anisimov Andrey, Zarkada Georgia, Holopainen Tanja, Hägerling René, Kiefer Friedemann, Eklund Lauri, Sormunen Raija, Elamaa Harri, Brekken Rolf A, Adams Ralf H, Koh Gou Young, Saharinen Pipsa, Alitalo Kari
Abstract excerpt
The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis. Here we found that Tie1 deletion from the endothelium of adult mice inhibits tumor angiogenesis and growth by decreasing endothelial cell survival in tumor vessels, without affecting normal vasculature. Treatment...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.