Article

Endothelial ANGPT2 insufficiency impairs retinal vascularization with ROP-like neovascular tufts

2026-08-17

Abstract excerpt

ANGPT2 is widely recognized as a critical regulator of pathological neovascularization. By analyzing scRNA-seq data from neonatal retinas, we demonstrate that Angpt2 transcripts are highly enriched in tip cells relative to other endothelial subtypes, where Angpt1 / 4 expression is absent. However, mechanisms underlying ANGPT2 function at angiogenic fronts remain inadequately understood. Here, we show that endot...

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Literature Corpus work: d7a3fbb9-1b52-579d-b946-2035903cdca8
DOI: 10.64898/2026.08.14.744858

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