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Article

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche

28 Mar 2019

Abstract excerpt

Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypomorphic Notch signaling. These heterozygous mice, which lack only one copy of the transcriptional activation domain, appear normal and have no endothelial or...

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Identifiers

PMID: 30923091
DOI: 10.3324/haematol.2018.208660

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