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Article

Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels.

The American journal of pathology - 1 Nov 2009

Falcón Beverly L, Hashizume Hiroya, Koumoutsakos Petros, Chou Jeyling, Bready James V, Coxon Angela, Oliner Jonathan D, McDonald Donald M

Abstract excerpt

Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis and vascular remodeling due to their effects on Tie2 receptor signaling. Ang2 blocks Ang1-mediated activation of Tie2 in endothelial cells under certain conditions but is a Tie2 receptor agonist in others. We exa...

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Identifiers

PMID: 19815705
DOI: 10.2353/ajpath.2009.090391
PMCID: PMC2774078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19815705-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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