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Article

Age-related and genetic modulation of frontal cortex efficiency.

Journal of cognitive neuroscience - 1 Apr 2014

Nyberg Lars, Andersson Micael, Kauppi Karolina, Lundquist Anders, Persson Jonas, Pudas Sara, Nilsson Lars-Göran

Abstract excerpt

The dorsolateral pFC (DLPFC) is a key region for working memory. It has been proposed that the DLPFC is dynamically recruited depending on task demands. By this view, high DLPFC recruitment for low-demanding tasks along with weak DLPFC upregulation at higher task demands reflects low efficiency. Here, the fMRI BOLD signal during working memory maintenance and manipulation was examined in relation to aging and...

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Source

Identifiers

PMID: 24236764
DOI: 10.1162/jocn_a_00521

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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