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Article

Decision-making and regret in patients with germline CDH1 variants undergoing prophylactic total gastrectomy.

Journal of medical genetics - 1 Mar 2023

Gamble Lauren A, Grant Robert R C, Samaranayake Sarah G, Fasaye Grace-Ann, Koh Christopher, Korman Louis, Asif Bilal, Heller Theo, Hernandez Jonathan M, Blakely Andrew M, Davis Jeremy L

Abstract excerpt

INTRODUCTION: Prophylactic total gastrectomy (PTG) can eliminate gastric cancer risk and is recommended in carriers of a germline CDH1 pathogenic variant. PTG has established risks and potential life-long morbidity. Decision-making regarding PTG is complex and not well-understood. METHODS: Individuals with germline CDH1 pathogenic or likely pathogenic variants who underwent surveillance endoscopy and recommended...

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Identifiers

PMID: 35817563
DOI: 10.1136/jmg-2022-108733
PMCID: PMC10248794

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