Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Psychosocial Impacts of Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer: A Narrative Review.

Psycho-oncology - 1 Oct 2025

Kearns Olivia, Snyder Deborah, Davis Jeremy, Gallanis Amber F, Lopez Rachael, Liu Michael, Raza Haniya

Abstract excerpt

BACKGROUND: Pathogenic or likely pathogenic (P/LP) CDH1 germline genetic variants are causally linked to early onset diffuse gastric cancer and prophylactic total gastrectomy (PTG) is a recommended intervention for (P/LP) CDH1 variant carriers. However, PTG introduces fundamental challenges to a patient's quality of life (QOL) and psychological well-being. There is a growing need for evidence-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Anxiety
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to Gastrectomy

Share to Genetic Predisposition to Disease

Share to Quality of Life

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41130910
DOI: 10.1002/pon.70304
PMCID: PMC12549222

Genes

CDH1
CTNNA1
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Psychosocial Impacts of Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer: A Narrative Review.PMID 41130910Read ↗

The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study.Semantic proximity Read ↗

Unique challenges of risk-reducing surgery for hereditary diffuse gastric cancer syndrome: a narrative review.Semantic proximity Read ↗

Long-term Outcomes of Prophylactic Total Gastrectomy in Patients with Hereditary Diffuse Gastric CancerSemantic proximity Read ↗

Costs of Cancer Prevention: Physical and Psychosocial Sequelae of Risk-Reducing Total Gastrectomy.Semantic proximity Read ↗

The Psychosocial Impact of Undergoing Prophylactic Total Gastrectomy (PTG) to Manage the Risk of Hereditary Diffuse Gastric Cancer (HDGC).Semantic proximity Read ↗

Emerging Adults Carrying a CDH1 Pathogenic or Likely Pathogenic Variant Face Diet and Lifestyle Challenges after Total Gastrectomy.Semantic proximity Read ↗

Outcomes after prophylactic gastrectomy for hereditary diffuse gastric cancer.Semantic proximity Read ↗

CDH1 variants leading to gastric cancer risk management decision-making experiences in emerging adults: 'I am not ready yet'.Semantic proximity Read ↗

Short and long-term outcomes of prophylactic total gastrectomy in 54 consecutive individuals with germline pathogenic mutations in the CDH1 gene.Semantic proximity Read ↗

International Delphi consensus guidelines for follow-up after prophylactic total gastrectomy: the Life after Prophylactic Total Gastrectomy (LAP-TG) study.Semantic proximity Read ↗

An investigation of the factors effecting high-risk individuals' decision-making about prophylactic total gastrectomy and surveillance for hereditary diffuse gastric cancer (HDGC).Semantic proximity Read ↗

Points to consider regarding prophylactic total gastrectomy in germline CDH1 variant carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.