Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

PloS one - 1 Jan 2014

Figueira Marisol, Moschioni Monica, De Angelis Gabriella, Barocchi Michèle, Sabharwal Vishakha, Masignani Vega, Pelton Stephen I

Abstract excerpt

UNLABELLED: The pneumococcal Pilus-1 enhances attachment to epithelial cells in the respiratory tract and subsequent invasion. Pilus-1 expression is bi-stable and positively regulated by the RlrA transcriptional regulator. To delineate the role of pilus-1 in Experimental Otitis Media (EOM), we evaluated colonization and disease due to a Streptococcus pneumoniae (SP) wild type strain (Taiwan19F-14 wt) and its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colony Count, Microbial
Share to Ear, Middle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fimbriae, Bacterial

Share to Immunization

Share to Nasopharynx

Share to Otitis Media

Share to Pneumococcal Vaccines

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 24421906
DOI: 10.1371/journal.pone.0083798
PMCID: PMC3885439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].PMID 24421906Read ↗

A novel streptococcal cell–cell communication peptide promotes pneumococcal virulence and biofilm formationSemantic proximity Read ↗

Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection nichesSemantic proximity Read ↗

Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunitySemantic proximity Read ↗

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae.Semantic proximity Read ↗

A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and ChinchillasSemantic proximity Read ↗

A pneumococcal pilus influences virulence and host inflammatory responses.Semantic proximity Read ↗

Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media.Semantic proximity Read ↗

Genetic requirement for pneumococcal ear infection.Semantic proximity Read ↗

Promiscuous signaling by a regulatory system unique to the pandemic PMEN1 pneumococcal lineage.Semantic proximity Read ↗

Bacterial surface lipoproteins mediate epithelial microinvasion by <i>Streptococcus pneumoniae</i>Semantic proximity Read ↗

<i>In vitro</i> phenotypic and transcriptomic variation in <i>Neisseria musculi</i> morphotypes correlate with colonization variability and persistence <i>in vivo</i>Semantic proximity Read ↗

Conserved mutations in the pneumococcal bacteriocin transporter gene, blpA, result in a complex population consisting of producers and cheaters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.