Article
A pneumococcal pilus influences virulence and host inflammatory responses.
Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006
Barocchi M A, Ries J, Zogaj X, Hemsley C, Albiger B, Kanth A, Dahlberg S, Fernebro J, Moschioni M, Masignani V, Hultenby K, Taddei A R, Beiter K, Wartha F, von Euler A, Covacci A, Holden D W, Normark S, Rappuoli R, Henriques-Normark B
Abstract excerpt
Streptococcus pneumoniae (pneumococcus) is a major cause of morbidity and mortality world-wide. The initial event in invasive pneumococcal disease is the attachment of encapsulated pneumococci to epithelial cells in the upper respiratory tract. This work provides evidence that initial bacterial adhesion and subsequent ability to cause invasive disease is enhanced by pili, long organelles able to extend beyond the...
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