Article

Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity

2025-12-17

Abstract excerpt

Streptococcus pneumoniae (Spn) colonization of the nasopharynx is a prerequisite for transmission and invasive disease. To investigate how repeated asymptomatic colonization shapes immunity and influences bacterial traits, we developed the Repeated Asymptomatic Murine Pneumococcal Colonization (RAMPC₃) model using strains belonging to serotypes: 2 (D39), 3 (WU2), and 4 (TIGR4). Sequential colonization revealed str...

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Literature Corpus work: d2d6cc0e-7910-5644-9e68-ff654d893cf8
DOI: 10.64898/2025.12.17.694863

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