Article
Conserved mutations in the pneumococcal bacteriocin transporter gene, blpA, result in a complex population consisting of producers and cheaters.
mBio - 1 Jan 2011
Son Matthew R, Shchepetov Mikhail, Adrian Peter V, Madhi Shabir A, de Gouveia Linda, von Gottberg Anne, Klugman Keith P, Weiser Jeffrey N, Dawid Suzanne
Abstract excerpt
UNLABELLED: All fully sequenced strains of Streptococcus pneumoniae possess a version of the blp locus, which is responsible for bacteriocin production and immunity. Activation of the blp locus is stimulated by accumulation of the peptide pheromone, BlpC, following its secretion by the ABC transporter, BlpA. The blp locus is characterized by significant diversity in blpC type and in the region of the locus...
Topics
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Animals
- Bacteriocins
- Base Sequence
- Cluster Analysis
- Female
- Frameshift Mutation
- Genetic Variation
- Humans