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Article

Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media.

PloS one - 9 Apr 2008

Forbes Michael L, Horsey Edward, Hiller N Luisa, Buchinsky Farrel J, Hayes Jay D, Compliment James M, Hillman Todd, Ezzo Suzanne, Shen Kai, Keefe Randy, Barbadora Karen, Post J Christopher, Hu Fen Ze, Ehrlich Garth D

Abstract excerpt

BACKGROUND: Streptococcus pneumoniae [Sp] infection is associated with local and systemic disease. Our current understanding of the differential contributions of genetic strain variation, serotype, and host response to disease phenotype is incomplete. Using the chinchilla model of otitis media [OM] we investigated the disease phenotype generated by the laboratory strain TIGR4 and each of thirteen clinical strains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18398481
DOI: 10.1371/journal.pone.0001969
PMCID: PMC2279396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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