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Article

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae.

Infection and immunity - 7 May 2024

Chan Jia Mun, Ramos-Sevillano Elisa, Betts Modupeh, Wilson Holly U, Weight Caroline M, Houhou-Ousalah Ambrine, Pollara Gabriele, Brown Jeremy S, Heyderman Robert S

Abstract excerpt

Streptococcus pneumoniae, a common colonizer of the upper respiratory tract, invades nasopharyngeal epithelial cells without causing disease in healthy participants of controlled human infection studies. We hypothesized that surface expression of pneumococcal lipoproteins, recognized by the innate immune receptor TLR2, mediates epithelial microinvasion. Mutation of lgt in serotype 4 (TIGR4) and serotype 6B...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38629841
DOI: 10.1128/iai.00447-23
PMCID: PMC11075461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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