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Article

The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.

Acta crystallographica. Section D, Biological crystallography - 1 Jan 2014

Cao Qin, Wang Xiao-Jun, Li Lan-Fen, Su Xiao-Dong

Abstract excerpt

Caspase 6 (CASP6) is a neuron degeneration-related protease and is widely considered to be a potential drug-design target against neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. The N-terminal pro-peptide of CASP6, also referred to as the pro-domain, contains 23 residues and its functional role remains elusive. In this study, the crystal structure of a full-length CASP6 zymogen...

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Source

Identifiers

PMID: 24419379
DOI: 10.1107/S1399004713024218

Genes

CASP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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