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Article

Mutations in the procaspase-3 dimer interface affect the activity of the zymogen.

Biochemistry - 28 Oct 2003

Pop Cristina, Feeney Brett, Tripathy Ashutosh, Clark A Clay

Abstract excerpt

The interface of the procaspase-3 dimer plays a critical role in zymogen maturation. We show that replacement of valine 266, the residue at the center of the procaspase-3 dimer interface, with glutamate resulted in an increase in enzyme activity of approximately 60-fold, representing a pseudoactivation of the procaspase. In contrast, substitution of V266 with histidine abolished the activity of the procaspase-3...

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Identifiers

PMID: 14567692
DOI: 10.1021/bi034999p
PMCID: PMC3110659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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