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Article

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches.

Journal of visualized experiments : JoVE - 13 Oct 2022

Nilov Dmitry K, Zamaraev Alexey V, Zhivotovsky Boris, Kopeina Gelina S

Abstract excerpt

Apoptosis is a type of programmed cell death that eliminates damaged cells and controls the development and tissue homeostasis of multicellular organisms. Caspases, a family of cysteine proteases, play a key role in apoptosis initiation and execution. The maturation of caspases and their activity is fine-tuned by post-translational modifications in a highly dynamic fashion. To assess the effect of...

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PMID: 36314804
DOI: 10.3791/64206

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